Endocrine Abstracts

Introduction: Hypercalcaemia is a commonly encountered biochemical abnormality. The most common causes of hypercalcaemia are primary hyperparathyroidism and malignancy. Familial Hypocalciuric Hypercalcaemia (FHH) is a rare cause of hypercalcaemia.Case: We present a 53-year-old female, who was referred to the endocrinology clinic for further investigation of a persistent hypercalcaemia associated with low-to-normal parathyroid hormone level (1.5pmol/l). S...

Objective: To investigate the relationship of thyroid hormones and insulin secretions in glucose homeostasis in impaired glucose tolerant and type 2 diabetic subjects, with normal thyroid functions.Methods: Retrospective cross sectional analysis was carried out on (n=266) impaired glucose tolerant, type 2 diabetics and normal glucose tolerant subjects. Thyrotropin (TSH), total triiodothyronine (TT3), total thyroxin (TT4) and ...

Diabetes mellitus, characterised primarily by hyperglycaemia, is associated with a number of cellular stresses and changes that cause cardiomyocytes to adapt with those modifications that characterise the diabetic heart. Although orexins are cardiovascular regulators acting via the brain, little is known about their potentially critical roles in the heart. Orexins exert their actions by activating two distinct G protein coupled receptors, orexin-R1 (OXR1) amd orexin-R2 (OXR2)....